Haroldo A Toque Selected Research

Arginase

3/2019	Role of Arginase 2 in Systemic Metabolic Activity and Adipose Tissue Fatty Acid Metabolism in Diet-Induced Obese Mice.
2/2019	Hyperglycemia-impaired aortic vasorelaxation mediated through arginase elevation: Role of stress kinase pathways.
1/2019	Mechanisms of obesity-induced metabolic and vascular dysfunctions.
1/2018	Arginase: A Multifaceted Enzyme Important in Health and Disease.
1/2018	Arginase 1 promotes retinal neurovascular protection from ischemia through suppression of macrophage inflammatory responses.
11/2017	Obesity-induced vascular inflammation involves elevated arginase activity.
11/2017	Obesity-induced vascular dysfunction and arterial stiffening requires endothelial cell arginase 1.
2/2016	Deregulation of arginase induces bone complications in high-fat/high-sucrose diet diabetic mouse model.
3/2015	Arginase inhibition enhances angiogenesis in endothelial cells exposed to hypoxia.
1/2015	Correction: angiotensin II-induced arterial thickening, fibrosis and stiffening involves elevated arginase function.

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Haroldo A Toque Research Topics

Disease

8	Erectile Dysfunction 12/2014 - 12/2010
5	Inflammation (Inflammations) 03/2019 - 01/2017
5	Obesity 03/2019 - 05/2011
4	Hypertension (High Blood Pressure) 11/2017 - 12/2011
4	Fibrosis (Cirrhosis) 11/2017 - 01/2013
3	Hyperglycemia 02/2019 - 09/2013
2	Cardiovascular Diseases (Cardiovascular Disease) 01/2019 - 01/2015
2	Infections 01/2019 - 09/2013
2	Body Weight (Weight, Body) 11/2017 - 11/2017
2	Diabetic Retinopathy (Retinopathy, Diabetic) 06/2017 - 01/2013
2	Hypoxia (Hypoxemia) 03/2015 - 11/2011
1	Respiratory Tract Infections (Respiratory Tract Infection) 01/2021
1	Pneumococcal Pneumonia 01/2021
1	Acute Lung Injury 01/2019
1	Type 2 Diabetes Mellitus (MODY) 01/2019
1	Mitochondrial Diseases (Mitochondrial Disease) 01/2019
1	Insulin Resistance 01/2019
1	Nephritis 01/2019
1	Proteinuria 01/2019
1	Ischemia 01/2018
1	Neoplasms (Cancer) 01/2018
1	Weight Gain 11/2017
1	Hypercholesterolemia 11/2017
1	Metabolic Syndrome (Dysmetabolic Syndrome X) 11/2017
1	Atherosclerosis 10/2017
1	Hemorrhagic Shock 01/2017
1	Osteoporosis 02/2016
1	Diabetes Complications 02/2016
1	Vascular Diseases (Vascular Disease) 03/2015
1	Edema (Dropsy) 09/2013
1	Pathologic Neovascularization 09/2013
1	Hyperoxia 09/2013
1	Papilledema 09/2013
1	Type 1 Diabetes Mellitus (Autoimmune Diabetes) 03/2013
1	Blindness (Hysterical Blindness) 01/2013
1	Vascular System Injuries 01/2013
1	Vascular Remodeling 11/2011
1	Right Ventricular Hypertrophy 11/2011
1	Pulmonary Hypertension 11/2011

Drug/Important Bio-Agent (IBA)

18	ArginaseIBA 03/2019 - 12/2010
6	Nitric Oxide (Nitrogen Monoxide)FDA Link 11/2017 - 12/2011
5	Protein Isoforms (Isoforms)IBA 03/2019 - 01/2013
5	Arginine (L-Arginine)FDA Link 11/2017 - 12/2011
4	CollagenIBA 03/2019 - 11/2011
3	EnzymesIBA 03/2019 - 01/2015
3	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 03/2015 - 01/2013
2	OrnithineIBA 01/2018 - 11/2017
2	Retinaldehyde (Retinal)IBA 01/2018 - 01/2013
2	Blood Glucose (Blood Sugar)IBA 11/2017 - 11/2017
2	Proteins (Proteins, Gene)FDA Link 03/2015 - 01/2015
2	Angiotensin IIIBA 01/2015 - 01/2015
2	Nitric Oxide Synthase (NO Synthase)IBA 01/2015 - 12/2014
2	AntioxidantsIBA 11/2014 - 04/2013
1	Hydrogen Peroxide (Hydroperoxide)FDA LinkGeneric 01/2021
1	Oxidants (Oxidizing Agents)IBA 01/2021
1	MacrolidesIBA 01/2021
1	InflammasomesIBA 01/2021
1	Penicillins (Penicillin)FDA Link 01/2021
1	Phosphotransferases (Kinase)IBA 02/2019
1	LectinsIBA 01/2019
1	pepBs1-Ac peptideIBA 01/2019
1	AdipokinesIBA 01/2019
1	Epithelial Sodium ChannelsIBA 01/2019
1	Tumor Necrosis Factor Receptors (Tumor Necrosis Factor Receptor)IBA 01/2019
1	NitrogenIBA 01/2019
1	Urea (Carbamide)FDA LinkGeneric 01/2019
1	UreohydrolasesIBA 01/2018
1	Insulin (Novolin)FDA Link 11/2017
1	PolyaminesIBA 11/2017
1	Proline (L-Proline)FDA Link 11/2017
1	AcidsIBA 11/2017
1	Adenosine (Adenocard)FDA LinkGeneric 10/2017
1	S-AdenosylhomocysteineIBA 10/2017
1	AdenosylhomocysteinaseIBA 10/2017
1	Adenosine KinaseIBA 10/2017
1	Reactive Oxygen Species (Oxygen Radicals)IBA 06/2017
1	Netrin-1IBA 01/2017
1	DCC ReceptorIBA 01/2017
1	Proliferating Cell Nuclear Antigen (PCNA)IBA 01/2015
1	Hydroxyproline (4 Hydroxyproline)IBA 01/2015
1	rho-Associated KinasesIBA 06/2013
1	Superoxides (Superoxide)IBA 04/2013
1	NADPH Oxidases (NAD(P)H oxidase)IBA 04/2013
1	SaltsIBA 01/2013
1	MineralocorticoidsIBA 01/2013
1	Desoxycorticosterone (Deoxycorticosterone)IBA 01/2013
1	Antihypertensive Agents (Antihypertensives)IBA 01/2013
1	Acetates (Acetic Acid Esters)FDA Link 01/2013
1	Desoxycorticosterone Acetate (DOCA)FDA Link 01/2013
1	Extracellular Signal-Regulated MAP Kinases (Extracellular Signal Regulated Kinases)IBA 12/2011
1	CalpainIBA 11/2011
1	MonocrotalineIBA 11/2011
1	calpain inhibitorsIBA 11/2011
1	Intercellular Signaling Peptides and Proteins (Growth Factors)IBA 11/2011

Therapy/Procedure

6	Therapeutics 01/2019 - 01/2013
1	Resuscitation 01/2017
1	Intraocular Injections 09/2013
1	Light Coagulation 09/2013
1	Lasers (Laser) 09/2013
1	Injections 09/2013